Chay santini biography of michael
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Abstract
Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have funnen evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment resistance in different cancer types. A role for autophagy in resistance to chemotherapies and targeted therapies has been described based largely on associations with various signaling pathways, including MAPK and PI3K/AKT signaling. However, our current understanding of the molecular mechanisms underlying the role of autophagy in facilitating treatment resistance remains limited. Here we provide a comprehensive summary of the evidence linking autophagy to major signaling pathways in the context of treatment resistance and tumor progression, and then highlight recently emerged molecular mechanisms underlying autophagy and the p62/KEAP1/NRF2 and FOXO3A/PUMA axes in chemores
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Chay Santini is a professional actress, spokesperson, model and host with both national and international experience in various entertainment markets. Her commercial credits, both in English and Spanish, begin at the age of three. Chay has shared both the small and silver screens with celebrities such as Will Sasso, Adam Sandler, Mario Lopez, Sofia Vergara, Geena Davis, Jay Mohr, Dan Marino, Natasha Henstridge, Roslyn Sanchez, Brett Roberts, Lillian Hurst, Francisco Zamora, Michael Stuart & Johanna Rosaly to name a few. Her formal training began in 1998 after being chosen as AVON's Latina Model of the Year. This opportunity awarded her with a scholarship which she used to study acting at the prestigious American Academy of Dramatic Arts in NYC. She was determined to hone her craft, so she continued studies at The School for Film and Television and Weist-Barron Studios. Following her move to Los Angeles, Chay took on-camera cold reading courses with Margie Haber and Courtne
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List of Puerto Ricans
This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.
This is a list of notable people from Puerto Rico which includes people who were born in Puerto Rico (Borinquen) and people who are of full or partial Puerto Rican descent. Puerto Rican citizens are included, as the government of Puerto Rico has been issuing "Certificates of Puerto Rican Citizenship" to anyone born in Puerto Rico or to anyone born outside of Puerto Rico with at least one parent who was born in Puerto Rico since 2007.[1][2] Also included in the list are some long-term continental American and other residents or immigrants of other ethnic heritages who have made Puerto Rico their home and consider themselves to be Puerto Ricans.
The list is divided into categories and, in some cases, sub-categories, which best describe the field for which the subject is most noted.